Prof Mugesh, G.
Dean
| Inorganic and physical Chemistry
Indian Institute of Science, Bangalore
Karnataka
Expertise:
Organic Chemistry
174
Publications
14
Projects
7192
Scopus Citations
10655
CrossRef
13 Years 9 Months Total Experience
Scopus
7,192
Citations
42
h-index
CrossRef
10,655
Citations
49
h-index
Google Scholar
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Professional Recognition
Alexander von Humboldt Foundation Equipment Award
2005
Alexander von Humboldt Foundation
RSC West India Young Scientist Award
2010
Royal Society of Chemistry
IUPAC International Award
2005
International Union of Pure and Applied Chemistry
CDRI Award
2010
Central Drug Research Institute
Community & Membership
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Personal Details
Doctor of Philosophy
1998
N/A
Dean
Jan 2020 – Present
Indian Institute of Science, Bangalore
| Inorganic and physical Chemistry
Professor
Dec 2012 – Apr 2020
Indian Institute of Science, Bangalore
| Inorganic and physical Chemistry
Chemical Sciences
Scholarly Work
Regulation of Ferroptosis in Neuronal Cells
OtherInhibition of deiodinase 3 for treating neuropsychiatric disorder
CompletedPrevention of eNOS Uncoupling by enzyme Mimetics: A Novel Therapeutic Approach for the Treatment of Endothlial Dysfunction in Vascular Disease
OtherPeptide Aggregation in Neurodegenarative Diseases:Inhibition of Oxidative Amyloid-beta Aggregation by Antioxidant Nanozymes
CompletedPeptide Aggregation in Neurodegenerative Diseases: Metal-mediated Tyrosine and Histidine Modifications in Amyloid beta-Peptides
CompletedDevelopment of selenazole drugs as a novel class of anti-cancer agents targeting the immune regulatoryenzyme indoleamine 2,3-dioxygenase
CompletedGlutathione Peroxidase and Peroxynitrite Reductase Mimetics
CompletedBioinorganic Chemistry of Enzymatic Halogenations: Understanding the role of Redox Active Metalloproteins
CompletedAntibiotic Resistance and Zinc Hydrolases: Understanding the Role of Metallo-b-lactamases
CompletedAnti-Thyroid Drugs and Thyroid Hormone Synthesis
Completedelenocysteine-mediated Native Chemical Ligation: Towards Total Chemical Synthesis of Metalloproteins
CompletedApplication of Synthetic Organoselenium Compounds in Biochemical Deiodination Reactions
CompletedChemically Modified Proteases: Mimics of Iodothyronine Deiodinases
CompletedSynthetic Selenium compounds as Mimics of Selenoenzyme
OtherAntioxidant Activity Of The Anti-Inflammatory Compound Ebselen And Its Analogues : Role Of Nonbonded Interactions
Bio-inspired Materials : Antioxidant and Phosphotriesterase Nanozymes
Biomimetic Studies On Anti-Thyroid Drugs And Thyroid Hormone Synthesis
Biomimetic Studies on Tyrosine- and Phenolate- Based Ligands and their Metal Complexes
Deiodination of Thyroid Hormones by Iodothyronine Deiodinase Mimics
Design And Synthesis Of Novel Angiotensin Converting Enzyme (ACE) Inhibitors Having Antioxidant Activity
The Effect of Substituents and Solvents on the Deiodination Reactions of Thyroid Hormones by Iodothyronine Deiodinase Mimics
Halogen Bonding in the Structure and Biomimetic Dehalogenation of Thyroid Hormones and Halogenated Nucleosides
Metallo-β-Lactamase, Phosphotriesterase And Their Functional Mimics
Structure-Activity Correlation and Mechanistic Investigations of Glutathione Peroxidase-Like Catalytic Activity of Diaryl Diselenides
Synthetic Antioxidants : Structure-Activity Correlation Studies Of Glutathione Peroxidase Mimics And Peroxynitrite Scavengers
Design and Synthesis of Cyclic Diselenides and Selenenyl Sulfides for Biomimetic Applications
Development of New Synthetic Methodologies for Selenocysteine, Selenopeptides and β-Seleno Amino Acids
TYPE III DEIODINASE INHIBITORS AND USES THEREOF
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
Jerusalem
IL | INDIAN INSTITUTE OF SCIENCE
BANGALORE
IN | HADASIT MED RES SERVICE | INDIAN INST SCIENT
-
Patent No. :
US20190389799A1
Filed :
28-08-2019
Published :
17-08-2021
Granted
TYPE III DEIODINASE INHIBITORS AND USES THEREOF
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
Jerusalem
IL | INDIAN INSTITUTE OF SCIENCE
Bangalore
IN | HADASIT MED RES SERVICE | INDIAN INST SCIENT
-
Patent No. :
US20180215709A1
Filed :
14-09-2016
Published :
02-08-2018
Published
3,4-BROMO ODER -SULFONAT-SUBSTITUIERTE 1H-PYRROLE-2,5-DION-DERIVATE ALS TYPE III DEIODINASE (DIO3) INHIBITOREN ZUR BEHANDLUNG VON DEPRESSIONEN UND KREBS | DÉRIVÉS 1H-PYRROLE-2,5-DIONE SUBSTITUÉS 3,4-BROMO OU -SULFONATE EN TANT QU'INHIBITEURS DE DÉIODINASE
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
9112001 Jerusalem
IL
101672088 | Indian Institute Of Science
Bangalore 560012
IN
101405937
-
Patent No. :
EP3119768A1
Filed :
16-03-2015
Published :
25-01-2017
Published
INHIBITEURS DE LA DÉSIODINASE DE TYPE III ET LEURS UTILISATIONS | TYPE III DEIODINASE INHIBITORS AND USES THEREOF
HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
IL | INDIAN INSTITUTE OF SCIENCE
IN
-
Patent No. :
WO2015140792A1
Filed :
16-03-2015
Published :
24-09-2015
Published
Scholarly Publications
Platelet activation and ferroptosis mediated NETosis drives heme induced pulmonary thrombosis
Open AccessCorrection: Targeting the DIO3 enzyme using first-in-class inhibitors effectively suppresses tumor growth: a new paradigm in ovarian cancer treatment (Oncogene, (2021), 40, 44, (6248-6257), 10.1038/s41388-021-02020-z)
Open AccessQuercetin inhibits platelet activation and ER-stress mediated autophagy in response to extracellular histone
DIO3 depletion attenuates ovarian cancer growth via reduced glycolysis and alterations in glutamine metabolism
Open AccessFrom Phenols to Proteins: One-Pot Biosynthesis and Genetic Encoding of Chalcogen-Containing Tyrosine Analogues
Open Access
10.1002/anie.202520166
Crossref: 1
Non-covalent interactions in the structure and function of metalloenzymes and related systems
Confined Micellar Environments Modulate Thiol Reactivity and Nitrite Release From 4-Nitronaphthalimide Nitric Oxide Prodrugs
From Fenton reaction to ferroptosis: chemistry of metal complexes in regulated cell death by lipid peroxidation
Showing 1 to 8 of 174 publications