Systemic T-cell activation and IFN-γ activity in indeterminate severe hepatitis are reminiscent of hemophagocytic lymphohistiocytosis: Implications for T-cell- and IFN-γ-directed therapies.
Authors: Shim J; Park S; Venkateswaran S; Kumar D; Prince C; Parihar V; Maples L; Waller EK; Kugathasan S; Briones M; Lee M; Henry CJ; Prahalad S; Chandrakasan S
Frequency of HLA-DR+CD38hi T-cells identifies and quantifies T-cell activation in hemophagocytic lymphohistiocytosis, hyperinflammation, and immune regulatory disorders
Authors: Deepak Kumar; Thinh H. Nguyen; Carolyn M. Bennett; Chengyu Prince; Laura Lucas; Sunita Park; Taylor Lawrence; Karin Chappelle; Mariam Ishaq; Edmund K. Waller; Sampath Prahalad; Michael Briones; Shanmuganathan Chandrakasan
Distinguishing immune activation and inflammatory signatures of multisystem inflammatory syndrome in children (MIS-C) versus hemophagocytic lymphohistiocytosis (HLH)
T Cell-Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis (HLH) Occurs in Non-Asians and Is Associated with a T Cell Activation State that Is Comparable to Primary HLH