Ministry of Education
Umakant Sahu
VIDWAN ID: 682956

Prof Umakant Sahu

Male
Assistant Professor (Grade-I) | Department of Biochemical Engineering and Biotechnology
Indian Institute of Technology, Delhi
Expertise: Cell Biology
ORCID 0000-0002-7269-4430 Scopus 57217220588 ResearcherID AFN-1541-2022 Google Scholar jRxcii_1RUcC
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22 Publications
0 Projects
766 Scopus Citations
797 CrossRef
9 Months Total Experience
Publications
22 Total
Articles
22
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Scopus Scopus
766 Citations
11 h-index
CrossRef CrossRef
797 Citations
10 h-index
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Assistant Professor (Grade-I)
Dec 2025 – Present
Indian Institute of Technology, Delhi | Department of Biochemical Engineering and Biotechnology
Medical and Health Sciences
Cell Biology

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Scholarly Publications

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle

Journal Article
Molecular Cell. Year: 2025. Volume: 85 , Issue: 22 , Pages: 4215-4228.e9 .
Authors: Mushtaq A. Nengroo; Austin T. Klein; Heather S. Carr; Olivia Vidal-Cruchez; Umakant Sahu; Daniel J. McGrail; Nidhi Sahni; Niklas B. Thompson; Peter A. Faull; Peng Gao; John M. Asara; Hardik Shah; Marc L. Mendillo; Issam Ben-Sahra
DOI 10.1016/j.molcel.2025.10.002 Crossref Crossref: 9 Scopus Scopus: 12

Pyrimidines maintain mitochondrial pyruvate oxidation to support de novo lipogenesis

Journal Article
Science. Year: 2024. Volume: 383 , Issue: 6690 , Pages: 1484-1492 .
Authors: Sahu, U.; Villa, E.; Reczek, C.R.; Zhao, Z.; O’Hara, B.P.; Torno, M.D.; Mishra, R.; Shannon, W.D.; Asara, J.M.; Gao, P.; Shilatifard, A.; Chandel, N.S.; Ben-Sahra, I.
DOI 10.1126/science.adh2771 Crossref Crossref: 69 Scopus Scopus: 66

Trm1p, a Zn(II)₂Cys₆-type transcription factor, is essential for the transcriptional activation of genes of methanol utilization pathway, in Pichia pastoris.

Journal Article
Biochemical and Biophysical Research Communications. Year: 2014. Volume: 451 , Issue: 1 , Pages: 158-164 .
Authors: Sahu U; Krishna Rao K; Rangarajan PN
DOI 10.1016/j.bbrc.2014.07.094 Crossref Crossref: 46 Scopus Scopus: 44

Regulation of Acetate Metabolism and Acetyl Co-a Synthetase 1 (ACS1) Expression by Methanol Expression Regulator 1 (Mxr1p) in the Methylotrophic Yeast Pichia pastoris.

Open Access
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY. Year: 2015. Volume: 291 , Issue: 7 , Pages: 3648-3657 .
Authors: Sahu U; Rangarajan PN
DOI 10.1074/jbc.m115.673640 Crossref Crossref: 28 Scopus Scopus: 25

Cancer Cells Tune the Signaling Pathways to Empower de Novo Synthesis of Nucleotides.

Open Access
Journal Article
Cancers. Year: 2019. Volume: 11 , Issue: 5 , Pages: 688 .
Authors: Villa E; Ali ES; Sahu U; Ben-Sahra I
DOI 10.3390/cancers11050688 Crossref Crossref: 243 Scopus Scopus: 243

ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis.

Open Access
Journal Article
Molecular Cell. Year: 2020. Volume: 78 , Issue: 6 , Pages: 1178-1191.e6 .
Authors: Ali ES; Sahu U; Villa E; O'Hara BP; Gao P; Beaudet C; Wood AW; Asara JM; Ben-Sahra I
DOI 10.1016/j.molcel.2020.05.001 Crossref Crossref: 72 Scopus Scopus: 67

NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia.

Open Access
Journal Article
Science Advances. Year: 2021. Volume: 7 , Issue: 5 , Pages: eabc9781 .
Authors: Srivastava S; Sahu U; Zhou Y; Hogan AK; Sathyan KM; Bodner J; Huang J; Wong KA; Khalatyan N; Savas JN; Ntziachristos P; Ben-Sahra I; Foltz DR
DOI 10.1126/sciadv.abc9781 Crossref Crossref: 19 Scopus Scopus: 16

mTORC1 stimulates cell growth through SAM synthesis and m<sup>6</sup>A mRNA-dependent control of protein synthesis.

Open Access
Journal Article
Molecular Cell. Year: 2021. Volume: 81 , Issue: 10 , Pages: 2076-2093.e9 .
Authors: Villa E; Sahu U; O'Hara BP; Ali ES; Helmin KA; Asara JM; Gao P; Singer BD; Ben-Sahra I
DOI 10.1016/j.molcel.2021.03.009 Crossref Crossref: 171 Scopus Scopus: 161
Showing 1 to 8 of 22 publications