Ashwani Kumar Thakur
VIDWAN ID: 52253

Prof Ashwani Kumar Thakur

Male Doctor of Philosophy
Professor | Department of Biological Sciences and Bioengineering
Indian Institute of Technology, Kanpur (2019 - 2010)
Uttar Pradesh
Expertise: Biotechnology and Applied Microbiology
63 Publications
14 Projects
2798 Scopus Citations
2842 CrossRef
9 Years 8 Months Total Experience
Publications
63 Total
Articles
61
Chapters
1
Proceedings
1
Activity

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Scopus Scopus
2,798 Citations
24 h-index
CrossRef CrossRef
2,842 Citations
24 h-index
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Professional Recognition

Fellowship
2003
Alexander von Humboldt Fellow, Germany
Excellence in Teacher Award
2023
Indian Institute of Technology Kanpur
C.N.R. Rao Faculty Award 2023
2023
Indian Institute of Technology Kanpur

Community & Membership

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Indian Peptide Society
Life member
Jan 2012
Indian Biophysical Society
Life member
Jan 2013

Personal Details

Doctor of Philosophy
2002
N/A
Master of Science
1995
University of North Texas Health Science Center
Bachelor of Science
1993
KERALA UNIVERSITY OF HEALTH SCIENCES
Professor
Dec 2019 – May 2010
Indian Institute of Technology, Kanpur | Department of Biological Sciences and Bioengineering
Associate Professor
Jun 2015 – Dec 2019
Indian Institute of Technology, Kanpur
Assistant Professor
May 2010 – May 2015
Indian Institute of Technology, Kanpur
Medical and Health Sciences
Biotechnology and Applied Microbiology

Related Profiles

Scholarly Work

Decrypting The Pathways Of Amyloid Composite Structure Formation In Seed Storage Protein Bodies Of Legumes
Other
Agency: Department of Bio-Technology Role: Co-Principal Investigator
Unraveling The Molecular-To-Atomic Structure Of Plant Seed Storage Protein Bodies Containing Amyloidic Composites
Other
Role: Principal Investigator
Evaluation Of Antimicrobial Activity Of A Composite Tablet Purposed For Air Cooler
Completed
Role: Principal Investigator
To Explore The Role Of Eosinopils Associated Mechanisms Of Tissue Remodeling & Fibrosis in Asthma
Completed
Role: Co-Principal Investigator
Targeting multiple pathways by a single molecule as a therapeutic strategy in Huntington’s disease
Completed
Agency: Department of Bio-Technology Role: Principal Investigator
Evaluating therapeutic potential of polyglutamine aggregation peptide inhibitors through nanoparticle-based-delivery approach in Huntington’s disease
Completed
Agency: Department of Science and Technology Role: Principal Investigator
Elucidation Of Molecular And Immunological Mechanisms Of Neuroinflammation Associated To Autophagy And Neurodegeneration
Completed
Agency: Council of Scientific and Industrial Research Role: Co-Principal Investigator
Building a novel system for soot: measurement, toxicity assessment and source identification
Completed
Agency: Ministry of Environment and Forests Role: Co-Principal Investigator
Synthesis, characterization and delivery of nanoparticles containing peptide inhibitors of polyglutamine aggregation in Huntington’s disease
Completed
Agency: Department of Bio-Technology Role: Principal Investigator
Understanding basic self-assembly mechanism and characteristics of protein aggregates for nanomaterial applications
Completed
Agency: Department of Bio-Technology Role: Principal Investigator
Thematic unit of excellence on soft nanofabrication with application in energy, environment and bioplatformas
Completed
Agency: Department of Science and Technology Role: Co-Principal Investigator
Mechanism based peptide inhibitors of huntingtin fragment aggregation in Huntington’s disease
Completed
Agency: Department of Bio-Technology Role: Principal Investigator
Testing N-terminal sequences of huntingtin for inhibiting huntingtin fragment aggregation
Completed
Role: Principal Investigator
GRBMP-ENB, Ganga River Basin Management Plan
Completed
Agency: Ministry of Environment and Forests Role: Co-Principal Investigator
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COMBINATION OF FLUORENYLMETHYLOXYCARBONYL CONJUGATED AMINO ACIDS (FMOC-AA) AND MEMBRANE PERMEABILIZING AGENTS AGAINST GRAM-NEGATIVE BACTERI

INDIAN INSTITUTE OF TECHNOLOGY KANPUR
- Patent No. : IN201911023031A Filed : 11-06-2019
Published : 21-06-2019 Published

PEPTIDE ENCAPSULATED BIODEGRADABLE NANOPARTICLES FOR TREATMENT OF NEURODEGENERATIVE DISEASES AND PREPARATION METHOD THEREOF

INDIAN INSTITUTE OF TECHNOLOGY KANPUR
- Patent No. : IN201811024748A Filed : 03-07-2018
Published : 14-06-2019 Published

FULLERENE NANOPARTICLES AND COMPOSITIONS THEREOF FOR INHIBITING AUTOPHAGY

INDIAN INSTITUTE OF TECHNOLOGY KANPUR
- Patent No. : IN201711004577A Filed : 08-02-2017
Published : 10-08-2018 Published

ARGININE DERIVATIVES AS POLYGLUTAMINE AGGREGATION INHIBITORS

INDIAN INSTITUTE OF TECHNOLOGY KANPUR
- Patent No. : IN201611003335A Filed : 29-01-2016
Published : 17-11-2017 Published

METHOD OF EXTRACTION FOR A NON-IONIC SURFACTANT ADSORBED ON BIODEGRADABLE POLYMERIC NANOPARTICLES

INDIAN INSTITUTE OF TECHNOLOGY KANPUR
- Patent No. : IN201503003I1 Filed : 22-09-2015
Published : 24-03-2017 Published

A DRUG SCREENING PROCESS AND A DRUG FORMULATION FOR HUNTINGTON'S DISEASE

INDIAN INSTITUTE OF TECHNOLOGY KANPUR
- Patent No. : IN201501182I1 Filed : 28-04-2015
Published : 04-11-2016 Published

DISAGGREGATION AND SOLUBILIZATION OF SYNTHETIC POLYPEPTIDES

INDIAN INSTITUTE OF TECHNOLOGY - KANPUR
- Patent No. : IN201500757I1 Filed : 20-03-2015
Published : 30-09-2016 Published

Scholarly Publications

Mutational analysis of the structural organization of polyglutamine aggregates

Journal Article
Proceedings of the National Academy of Sciences (PNAS). Year: 2002. Volume: 99 , Issue: 26 , Pages: 17014-17019 .
Authors: Ashwani K. Thakur; Ronald Wetzel

Inhibition of polyglutamine aggregate cytotoxicity by a structure-based elongation inhibitor.

Journal Article
The FASEB Journal. Year: 2004. Volume: 18 , Issue: 7 , Pages: 923-925 .
Authors: Ashwani K. Thakur; Wen Yang; Ronald Wetzel

Polyglutamine aggregation nucleation: Thermodynamics of a highly unfavorable protein folding reaction

Journal Article
Proceedings of the National Academy of Sciences (PNAS). Year: 2005. Volume: 102 , Issue: 43 , Pages: 15400-15405 .
Authors: Anusri M. Bhattacharyya; Ashwani K. Thakur; Ronald Wetzel

Oligoproline effects on polyglutamine conformation and aggregation

Journal Article
Journal of Molecular Biology. Year: 2006. Volume: 355 , Issue: 3 , Pages: 524-535 .
Authors: Anusri Bhattacharyya; Ashwani K. Thakur; Veronique M. Chellgren; Geetha Thiagarajan; Angela D. Williams; Brian W. Chellgren; Trevor P. Creamer; Ronald Wetzel

CA150 expression delays striatal cell death in overexpression and knock-in conditions for mutant huntingtin neurotoxicity

Open Access
Journal Article
Journal of Neuroscience. Year: 2006. Volume: 26 , Issue: 17 , Pages: 4649-4659 .
Authors: Margarita Arango; Sébastien Holbert; Dania Zala; Emmanuel Brouillet; James Pearson; Etienne Régulier; Ashwani Kumar Thakur; Patrick Aebischer; Ronald Wetzel; Nicole Déglon; Christian Néri

Kinetics and Thermodynamics of Amyloid Assembly Using a High-Performance Liquid Chromatography-Based Sedimentation Assay

Review
Methods in Enzymology. Year: 2006. Volume: 413 , Pages: 34-74 .
Authors: Brian O'Nuallain; Ashwani K. Thakur; Angela D. Williams; Anusri M. Bhattacharyya; Songming Chen; Geetha Thiagarajan; Ronald Wetzel

In-cell aggregation of a polyglutamine-containing chimera is a multistep process initiated by the flanking sequence

Open Access
Journal Article
JOURNAL OF BIOLOGICAL CHEMISTRY. Year: 2007. Volume: 282 , Issue: 50 , Pages: 36736-36743 .
Authors: Zoya Ignatova; Ashwani K. Thakur; Ronald Wetzel; Lila M. Gierasch

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism

Journal Article
Nature Structural & Molecular Biology. Year: 2009. Volume: 16 , Issue: 4 , Pages: 380-389 .
Authors: Ashwani K Thakur; Murali Jayaraman; Rakesh Mishra; Monika Thakur; Veronique M Chellgren; In-Ja L Byeon; Dalaver H Anjum; Ravindra Kodali; Trevor P Creamer; James F Conway; Angela M Gronenborn; Ronald Wetzel
Showing 1 to 8 of 63 publications