Ministry of Education
Naga Rajiv Lakkaniga
VIDWAN ID: 336156

Dr Naga Rajiv Lakkaniga

Male Doctor of Philosophy
Assistant Professor | Department of Chemistry and Chemical Biology
Indian Institute of Technology (Indian School of Mines), Dhanbad
Jharkhand
Expertise: Multidisciplinary Chemistry
ORCID 0000-0001-8370-2224 Scopus 57200992795 ResearcherID ABC-4847-2020 Google Scholar i_z0Tu4AAAAJ
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33 Publications
2 Projects
857 Scopus Citations
814 CrossRef
5 Years 7 Months Total Experience
Publications
33 Total
Articles
33
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Scopus Scopus
857 Citations
17 h-index
CrossRef CrossRef
814 Citations
17 h-index
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Personal Details

Doctor of Philosophy
2020
N/A
Assistant Professor
Jan 2022 – Present
Indian Institute of Technology (Indian School of Mines), Dhanbad | Department of Chemistry and Chemical Biology
Post-Doctoral Research Associate
Feb 2021 – Dec 2021
The Scripps Research Institute, La Jolla, California, USA
Chemical Sciences
Multidisciplinary Chemistry

Related Profiles

Scholarly Work

Bioscopy - Towards modern transdisciplinary education and research in microscopy
Other
Agency: University Grants Commission Role: Co-Principal Investigator Grant: F.58-8/2024-27(IC/INCP2
Amount: ₹1.15 Crore
Duration: 2025 – Ongoing
Design, synthesis and biological evaluation of Monopolar spindle 1 inhibitors as potential therapeutics for triple negative breast cancer
Completed
Role: Principal Investigator Grant: SRG/2022/000091
Amount: ₹31.79 Lac
Duration: 2022 – 2024
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Scholarly Publications

Bioisosteric Discovery of NPA101.3, a Second-Generation RET/VEGFR2 Inhibitor Optimized for Single-Agent Polypharmacology

Open Access
Journal Article
Journal of Medicinal Chemistry. Year: 2020. Volume: 63 , Issue: 9 , Pages: 4506-4516 .
Authors: Marialuisa Moccia; Brendan Frett; Lingtian Zhang; Naga Rajiv Lakkaniga; David C. Briggs; Rakhee Chauhan; Annalisa Brescia; Giorgia Federico; Wei Yan; Massimo Santoro; Neil Q. McDonald; Hong-yu Li; Francesca Carlomagno
DOI 10.1021/acs.jmedchem.9b01336 Crossref Crossref: 27 Scopus Scopus: 25

Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor

Journal Article
European Journal of Medicinal Chemistry. Year: 2021. Volume: 225 , Pages: 113776 .
Authors: Lingtian Zhang; Naga Rajiv Lakkaniga; Jaideep B. Bharate; Nicholas Mcconnell; Xiuqi Wang; Anupreet Kharbanda; Yuet-Kin Leung; Brendan Frett; Neil P. Shah; Hong-yu Li
DOI 10.1016/j.ejmech.2021.113776 Crossref Crossref: 23 Scopus Scopus: 25

Novel hydroxybenzylamine-deoxyvasicinone hybrids as anticholinesterase therapeutics for Alzheimer’s disease

Journal Article
Bioorganic & Medicinal Chemistry. Year: 2021. Volume: 45 , Pages: 116311 .
Authors: Suresh K. Bowroju; Narsimha R. Penthala; Naga Rajiv Lakkaniga; Meenakshisundaram Balasubramaniam; Srinivas Ayyadevara; Robert J. Shmookler Reis; Peter A. Crooks
DOI 10.1016/j.bmc.2021.116311 Crossref Crossref: 20 Scopus Scopus: 24

Targeting Rearranged during Transfection in Cancer: A Perspective on Small-Molecule Inhibitors and Their Clinical Development

Journal Article
Journal of Medicinal Chemistry. Year: 2021. Volume: 64 , Issue: 16 , Pages: 11747-11773 .
Authors: Debasmita Saha; Katie Rose Ryan; Naga Rajiv Lakkaniga; Baku Acharya; Noemi Garcia Garcia; Erica Lane Smith; Brendan Frett
DOI 10.1021/acs.jmedchem.0c02167 Crossref Crossref: 37 Scopus Scopus: 36

Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases

Open Access
Journal Article
Scientific Reports. Year: 2021. Volume: 11 , Issue: 1 , Pages: 16103 .
Authors: Marialuisa Moccia; Donglin Yang; Naga Rajiv Lakkaniga; Brendan Frett; Nicholas McConnell; Lingtian Zhang; Annalisa Brescia; Giorgia Federico; Lingzhi Zhang; Paolo Salerno; Massimo Santoro; Hong-yu Li; Francesca Carlomagno
DOI 10.1038/s41598-021-95612-4 Crossref Crossref: 16 Scopus Scopus: 14

Pyrazoloadenine Inhibitors of the RET Lung Cancer Oncoprotein Discovered by a Fragment Optimization Approach

Journal Article
CHEMMEDCHEM (ELECTRONIC). Year: 2021. Volume: 16 , Issue: 10 , Pages: 1605-1608 .
Authors: Debasmita Saha; Katie Rose Ryan; Naga Rajiv Lakkaniga; Erica Lane Smith; Brendan Frett
DOI 10.1002/cmdc.202100013 Crossref Crossref: 6 Scopus Scopus: 7

FCX-146, a potent allosteric inhibitor of Akt kinase in cancer cells: Lead optimization of the second-generation arylidene indanone scaffold

Journal Article
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY. Year: 2021. Volume: 68 , Issue: 1 , Pages: 82-91 .
Authors: Balasubramaniam, M.; Lakkaniga, N.R.; Dera, A.A.; Fayi, M.A.; Abohashrh, M.; Ahmad, I.; Chandramoorthy, H.C.; Nalini, G.; Rajagopalan, P.
DOI 10.1002/bab.1896 Crossref Crossref: 22 Scopus Scopus: 21

Pyrrolo[2,3-d]pyrimidine derivatives as inhibitors of RET: Design, synthesis and biological evaluation

Journal Article
European Journal of Medicinal Chemistry. Year: 2020. Volume: 206 , Pages: 112691 .
Authors: Naga Rajiv Lakkaniga; Naresh Gunaganti; Lingtian Zhang; Binyam Belachew; Brendan Frett; Yuet-Kin Leung; Hong-yu Li
DOI 10.1016/j.ejmech.2020.112691 Crossref Crossref: 29 Scopus Scopus: 30
Showing 1 to 8 of 33 publications