Activation of prolyl hydroxylase-2 for stabilization of mitochondrial stress along with simultaneous downregulation of HIF-1α/FASN in ER + breast cancer subtype.
Authors: Devi U; Singh M; Roy S; Gupta PS; Ansari MN; Saeedan AS; Kaithwas G
Repurposing mechanistic insight of PDE-5 inhibitor in cancer chemoprevention through mitochondrial-oxidative stress intervention and blockade of DuCLOX signalling
DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention
Other
Year: 2018.
Authors: Swetlana Gautam; Atul Rawat; Shreesh Raj Sammi; Subhadeep Roy; Manjari Singh; Uma Devi; Rajnish Kumar Yadav; Lakhveer Singh; Jitendra K. Rawat; Mohd Nazam Ansari; Abdulaziz S. Saeedan; Dinesh Kumar; Rakesh Pandey; Gaurav Kaithwas
Chemical activation of prolyl hydroxylase-2 by BBAP-1 down regulates hypoxia inducible factor-1α and fatty acid synthase for mammary gland chemoprevention.